Broadly speaking, we explore quantitative questions in cellular biomechanics in both prokaryotes and eukaryotes. We use molecular level concepts, statistical mechanics and continuum mechanics to explain diverse biological phenomena such as cell movement, cell division and biological force generation. We are also interested in biological micro-structures and the fundamental properties of soft biological materials.

Recent Publications:

  1. Bioengineering paradigms for cell migration in confined microenvironments.  Stroka KM, Gu Z, Sun SX, Konstantopoulos K. Curr Opin Cell Biol.; 2014
  2. Coherent Motions in Confluent Cell Monolayer Sheets. Bo Li and Sean X. Sun Biophysical Journal; 2014
  3. Mechanochemical Regulation of Oscillatory Follicle Cell Dynamics in the Developing Drosophila Egg Chamber.  Sarita Koride, Li He, Li-Ping Xiong, Ganhui Lan, Denise J. Montell, and Sean X. Sun Molecular Biology of the Cell; 2014
  4. Water Permeation Drives Tumor Cell Migration in Confined Microenvironments.  K.M. Stroka*, H. Jiang*, S-H Chen, Z. Tong, D. Wirtz, S.X. Sun, and K. Konstantopoulos (*, equal contribution)  Cell ; 2014
  5. How Accurately Can a Single Receptor Measure Ligand Concentrations? Sean X. Sun Biophysical Journal, Volume 106, Issue 4, 778-779, ; 2014
  6. Three-Dimensional Cell Migration Does Not Follow a Random Walk. Wu, Pei-Hsun, Anjil Giri, Sean X. Sun, and Denis Wirtz Proceedings of the National Academy of Sciences; 2014